U2AF2 and IL7R

Data Source:
BioGRID (unspecified method)

		U2AF2	IL7R
Description		U2 small nuclear RNA auxiliary factor 2	interleukin 7 receptor
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GO Annotations	Cellular Component	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Membrane Organization Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		75 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CDC42 CHERP CHIC2 CPSF7 DACH1 DDX39B DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OTUB2 PHF5A PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 U2AF1L5 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		11338	3575
HPRD ID		01872	00893
Ensembl ID		ENSG00000063244	ENSG00000168685
Uniprot IDs		P26368	P16871
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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