RNF24 and TRPC6

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF24	TRPC6
Description		ring finger protein 24	transient receptor potential cation channel subfamily C member 6
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Endomembrane System Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Protein Ubiquitination	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia
Pathways			Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Nevirapine-induced hypersensitivity in HIV (drug-induced liver injury) ( 28062682) PR interval ( 32439900) Response to antidepressants in depression ( 27622933)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ABHD5 ARMC1 BNIP3 CNIH1 GOLT1A LHFPL3 MFSD14B NKG7 NRSN1 NT5E PLP1 SLC10A6 TIMMDC1 TMX2 TRPC6 UQCRH VAMP1	9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2
Entrez ID		11237	7225
HPRD ID		10198	04710
Ensembl ID		ENSG00000101236	ENSG00000137672
Uniprot IDs		Q9Y225	Q9Y210
PDB IDs		2EP4	5YX9 6UZ8 6UZA 7A6U
Enriched GO Terms of Interacting Partners?
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