TRPC6 and TRPC7

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TRPC6	TRPC7
Description		transient receptor potential cation channel subfamily C member 6	transient receptor potential cation channel subfamily C member 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm	Nuclear Envelope Cis-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Manganese Ion Transport Single Fertilization Platelet Activation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling	Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)	Body fat percentage ( 31752434) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Sleep duration (short sleep) ( 30846698)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	4 interacting genes: ITPR3 MX1 TRPC3 TRPC6
Entrez ID		7225	57113
HPRD ID		04710	18228
Ensembl ID		ENSG00000137672	ENSG00000069018
Uniprot IDs		Q9Y210	Q9HCX4
PDB IDs		5YX9 6UZ8 6UZA 7A6U
Enriched GO Terms of Interacting Partners?
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