LZTS1 and NEK6

Data Source:
BioGRID (two hybrid)

		LZTS1	NEK6
Description		leucine zipper tumor suppressor 1	NIMA related kinase 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Apical Plasma Membrane Dendritic Spine Dendritic Shaft Cell Body Postsynaptic Membrane	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	Protein Binding Microtubule Binding	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Macroautophagy Mitotic Cell Cycle Phase Transition Regulation Of Synaptic Plasticity Regulation Of Dendrite Morphogenesis	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence
Pathways			Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Influenza A (H1N1) infection ( 26379185) Major depressive disorder (broad) ( 20038947) Preeclampsia ( 23551011) Rheumatoid arthritis ( 30891314) Severe influenza A (H1N1) infection ( 26379185) Susceptibility to persistent hepatitis B virus infection ( 27244555)	Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)
Interacting Genes		100 interacting genes: AGTR1 AMOT AP1M1 BYSL CARD9 CCDC102B CCDC120 CCDC13 CCDC187 CCDC57 CCHCR1 CDC23 CDC25C CDC37 CDC7 CDK1 CEP83 CKS1B COG2 COPB1 CWF19L2 DDX6 EEF1G ELOA ENKD1 EXOC8 FAM161A FAM161B FAM50B FAM71F1 FAM81B FAM90A1 GAS8 GOLGA1 GPKOW HMGB2 IDO2 KANK2 KAT5 KAZN KDM1A KIF9 KIFC3 LENG1 LMNB2 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAPK9 MCRS1 METTL21A MFAP1 MID2 NEK6 NTAQ1 PIBF1 PICK1 PLEKHA7 POLR1C POLR3C PPP1R18 PRKAB2 PRPF18 PRPF3 PSMA1 PSPC1 QARS1 RABIF RHPN1 RSPH14 RUNX1T1 SCNM1 SGF29 SOGA1 SPDYC SUFU SYT17 SYT6 SYTL4 TBC1D1 TBC1D7 TCEA2 TSGA10 TSGA10IP TTC9C TXLNA TXLNB TXNDC9 UBASH3A ZGPAT ZMYND19 ZNF250 ZNF3 ZNF35 ZNF417 ZNF572 ZNF587	117 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEP76 CFP CIR1 COG6 CTBP2 DDIT4L DES DPH2 EFHC2 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TEX45 TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1
Entrez ID		11178	10783
HPRD ID		05945	05348
Ensembl ID		ENSG00000061337	ENSG00000119408
Uniprot IDs		Q9Y250	A0A024R8A6 Q9HC98
PDB IDs
Enriched GO Terms of Interacting Partners?
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