NEK6 and SH3RF2

Data Source:
BioGRID (two hybrid)

		NEK6	SH3RF2
Description		NIMA related kinase 6	SH3 domain containing ring finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Microtubule Nuclear Speck Protein-containing Complex Centriolar Satellite	Nucleus Nucleoplasm
	Molecular Function	Magnesium Ion Binding Transcription Corepressor Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Phosphatase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Mitotic Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Spindle Assembly Cell Division Regulation Of Cellular Senescence	Negative Regulation Of Phosphatase Activity Positive Regulation Of Cell Migration Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autoubiquitination
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 32296059) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Chronotype ( 30696823) Cognitive performance ( 20125193) Free thyroxine concentration ( 30367059) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Mercury levels ( 26025379) Neurociticism ( 29500382) Pulse pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Vitiligo ( 27723757)	Bacteremia ( 27236921) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261)
Interacting Genes		117 interacting genes: ANKRA2 ARHGAP33 ARRB1 ATF4 BEND7 BHLHE40 CBY2 CCDC120 CCDC136 CCDC85B CDC42 CDK7 CEP76 CFP CIR1 COG6 CTBP2 DDIT4L DES DPH2 EFHC2 ERCC6L2 FAM220A FHL5 FOXJ3 GFAP GIGYF1 GLIS3 GOLGA6L2 GRIP1 HOMEZ HOOK2 HOXA1 HOXB6 HSD17B14 IHO1 IKZF1 IKZF3 INCA1 KATNBL1 KCTD5 KIAA1328 KRT31 KRT34 KRT40 KRT75 KRT8 KRTAP10-8 KRTAP13-1 KRTAP13-3 LNX1 LZTS1 LZTS2 MBD3L1 MEOX2 METTL15 MYOG MYOZ3 NECAB2 NEFL NEK9 NIF3L1 NUDT16L1 PAK6 PBX4 PHF1 PICK1 PIN1 PLEKHA7 PPP1R16A PRAM1 PRDM16 PRDM6 PRDX3 PRICKLE4 PTN PTPN21 PTPRD RBAK RBBP6 RIMBP3C RPS6KB1 RPS7 SAXO1 SGK1 SH3RF2 SMAD4 SMUG1 SMURF2 SORBS3 SPRY3 TASOR2 TCF12 TCF4 TEPSIN TEX45 TFIP11 TGFBR1 TLE5 TNK2 TRAF2 TRIM23 TRIM27 TRIM54 TRIP4 UBXN11 XIAP ZC2HC1C ZCCHC7 ZFP90 ZNF24 ZNF343 ZNF438 ZNF587 ZNF688 ZNF774 ZRANB1	23 interacting genes: AKAP8L AMOTL2 APP ATXN7L2 BAG4 BANP CBY2 CCDC102B CYSRT1 EFS FASLG GOLGA2 HOMEZ LMNA LZTS2 MTUS2 NEK6 PAK4 PPP1CA PPP1CC RBPMS UBE2N VPS37C
Entrez ID		10783	153769
HPRD ID		05348	10229
Ensembl ID		ENSG00000119408	ENSG00000156463
Uniprot IDs		A0A024R8A6 Q9HC98	Q08AM8 Q8TEC5
PDB IDs
Enriched GO Terms of Interacting Partners?
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