ERG28 and PEX2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ERG28	PEX2
Description		ergosterol biosynthesis 28 homolog	peroxisomal biogenesis factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Transport Vesicle	Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Membrane Cdc73/Paf1 Complex
	Molecular Function	Molecular_function Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding	Protein Binding Metal Ion Binding
	Biological Process	Biological_process Sterol Biosynthetic Process	Very Long-chain Fatty Acid Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination Protein Destabilization Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			Fasting plasma glucose ( 31170924) Height ( 20881960 31562340) Infant length ( 25281659) Menarche (age at onset) ( 27182965 25231870) Nicotine dependence ( 28440896) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		124 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 AQP3 AQP6 BAIAP2 BCL2L13 BID BTBD2 CCDC106 CCL18 CD53 CD74 CDC42 CDK5RAP2 CELF3 CLDN5 CLDN7 CLN8 COX17 CRADD CREB1 CREB3 CREB3L1 CSTF2 CYB561 DYNLL1 EBP ELOVL4 ERBB2 ERBB3 ERBB4 FAM174A FAM209A FAS FCGR2B FFAR2 FXR1 FXYD3 GADD45A GET1 GJB5 GPR152 GPR37L1 GPX8 GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSD17B11 HSPE1 HTR2C HYLS1 JAGN1 KCNJ6 KLHL20 LHFPL5 LMNA LSM2 LYPD5 MAPK8IP2 MFSD14B MGST3 MPHOSPH6 MRM1 MRPL38 MRPS12 MS4A3 MSMO1 MTERF3 MTNR1B MUC1 NAT9 NCR3LG1 NDUFA3 NDUFA4L2 NR1H2 NSF PAFAH1B3 PCDHA4 PDZK1IP1 PEX2 PFN1 PHYHIP PIGY POLE2 POLR2C POLR3F PPP1R8 PQBP1 PSCA RAB27A REEP4 RETREG3 RPS6KA6 S100A8 SAR1A SAT1 SCN3B SEPHS1 SERPINB9 SGPL1 SLC10A6 SLC26A6 SLC34A2 SNRPB SNRPG SSMEM1 STOM STX1A SULT1E1 TFG TK1 TLCD4 TM4SF19 TMEM106A TMEM222 TMEM31 TMPRSS2 TSC22D1 TTR ZFP64 ZNF24	4 interacting genes: APP ERG28 PEX10 TLE1
Entrez ID		11161	5828
HPRD ID		05201	01367
Ensembl ID		ENSG00000133935	ENSG00000164751
Uniprot IDs		Q6FII3 Q86TW5 Q9UKR5	P28328
PDB IDs
Enriched GO Terms of Interacting Partners?
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