ERG28 and ANXA1

Data Source:
BioGRID (two hybrid)

		ERG28	ANXA1
Description		ergosterol biosynthesis 28 homolog	annexin A1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Transport Vesicle	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Motile Cilium Early Endosome Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Sarcolemma Mast Cell Granule Collagen-containing Extracellular Matrix Extracellular Exosome Synaptic Membrane
	Molecular Function	Molecular_function Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding	Single-stranded DNA Binding Single-stranded RNA Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Double-stranded DNA Helicase Activity Identical Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion DNA/DNA Annealing Activity
	Biological Process	Biological_process Sterol Biosynthetic Process	Neutrophil Homeostasis Adaptive Immune Response Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Response To X-ray Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Cytokine-mediated Signaling Pathway Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Actin Cytoskeleton Reorganization Response To Estradiol DNA Duplex Unwinding Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Gliogenesis Positive Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Estrous Cycle Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity
Pathways			G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling
Drugs			Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate
Diseases
GWAS			Blood protein levels ( 28240269) Chronotype ( 30696823) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)
Interacting Genes		124 interacting genes: ALDH2 ANXA1 ANXA7 AQP2 AQP3 AQP6 BAIAP2 BCL2L13 BID BTBD2 CCDC106 CCL18 CD53 CD74 CDC42 CDK5RAP2 CELF3 CLDN5 CLDN7 CLN8 COX17 CRADD CREB1 CREB3 CREB3L1 CSTF2 CYB561 DYNLL1 EBP ELOVL4 ERBB2 ERBB3 ERBB4 FAM174A FAM209A FAS FCGR2B FFAR2 FXR1 FXYD3 GADD45A GET1 GJB5 GPR152 GPR37L1 GPX8 GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSD17B11 HSPE1 HTR2C HYLS1 JAGN1 KCNJ6 KLHL20 LHFPL5 LMNA LSM2 LYPD5 MAPK8IP2 MFSD14B MGST3 MPHOSPH6 MRM1 MRPL38 MRPS12 MS4A3 MSMO1 MTERF3 MTNR1B MUC1 NAT9 NCR3LG1 NDUFA3 NDUFA4L2 NR1H2 NSF PAFAH1B3 PCDHA4 PDZK1IP1 PEX2 PFN1 PHYHIP PIGY POLE2 POLR2C POLR3F PPP1R8 PQBP1 PSCA RAB27A REEP4 RETREG3 RPS6KA6 S100A8 SAR1A SAT1 SCN3B SEPHS1 SERPINB9 SGPL1 SLC10A6 SLC26A6 SLC34A2 SNRPB SNRPG SSMEM1 STOM STX1A SULT1E1 TFG TK1 TLCD4 TM4SF19 TMEM106A TMEM222 TMEM31 TMPRSS2 TSC22D1 TTR ZFP64 ZNF24	34 interacting genes: APBB1 CCT7 COPS6 CSAD CZIB DYSF EGFR ERG28 FAF1 FPR1 GAPDH HMGA1 HSPB1 KLHL23 KMT2B KRT8 LNPK LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC SUMO2 TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 USP7 YWHAQ
Entrez ID		11161	301
HPRD ID		05201	01060
Ensembl ID		ENSG00000133935	ENSG00000135046
Uniprot IDs		Q6FII3 Q86TW5 Q9UKR5	P04083 Q5TZZ9
PDB IDs			1AIN 1BO9 1QLS 5VFW
Enriched GO Terms of Interacting Partners?
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