KAT7 and ZNF165

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KAT7	ZNF165
Description		lysine acetyltransferase 7	zinc finger protein 165
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Histone H3-K14 Acetyltransferase Complex Site Of DNA Damage	Nucleus
	Molecular Function	DNA Replication Origin Binding Transcription Coregulator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Natural Killer Cell Differentiation DNA Replication DNA Repair Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Regulation Of DNA-dependent DNA Replication Initiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of DNA-templated Transcription, Elongation Histone H3 Acetylation Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Sorbitol Response To Hydroxyurea Response To Actinomycin D Response To Dithiothreitol Response To Anisomycin Positive Regulation Of Histone H4 Acetylation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Nucleotide-excision Repair	Regulation Of Transcription By RNA Polymerase II
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Mean reticulocyte volume ( 32888494)	Apolipoprotein B levels ( 32203549) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Hepcidin/ferritin ratio ( 27846281) LDL cholesterol levels ( 32203549) Moderate to vigorous physical activity levels ( 29899525) Refractive error ( 32231278) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		44 interacting genes: APP AR ATN1 BARD1 CAAP1 CALCOCO2 CBX8 CDC6 CDK11B CEP126 CEP70 CSNK1E DDX11 DVL3 DYNC1I1 GMNN H2AC20 H3C1 H4C1 HAP1 HOOK2 ING4 KATNBL1 KCTD13 LRIF1 MAP2K1 MCM2 MCRS1 NINL ORC1 ORC2 PACSIN1 POLB PPID RGL2 RPS10 SAT1 SEPTIN5 SNAPIN TP53 VIM WDR33 ZBTB8A ZNF165	46 interacting genes: AHCYL1 CARD10 CCDC125 CCDC130 CCDC85B CEP70 DVL2 DVL3 ELOA2 EMD EWSR1 FAM124A GOLGA6L9 GPATCH2L HOMEZ IL16 KAT7 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 MAB21L3 MID2 NTAQ1 PDLIM7 PICK1 PLEKHF2 PPL RNPS1 SCAND1 SUV39H1 TRIM41 ZKSCAN8 ZNF24 ZNF250 ZNF263 ZNF417 ZNF446 ZNF572 ZNF668 ZNF774 ZNF837
Entrez ID		11143	7718
HPRD ID		07135	02903
Ensembl ID		ENSG00000136504	ENSG00000197279
Uniprot IDs		O95251	P49910 Q53Z40
PDB IDs		5GK9 6MAJ 6MAK
Enriched GO Terms of Interacting Partners?
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