TLK2 and DOCK1

Data Source:
BioGRID (affinity chromatography technology)

		TLK2	DOCK1
Description		tousled like kinase 2	dedicator of cytokinesis 1
Image
GO Annotations	Cellular Component	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Positive Regulation Of Epithelial Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		Fostamatinib
Diseases
GWAS		Heel bone mineral density ( 30598549) Lifespan ( 25918517)	Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ	11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2
Entrez ID		11011	1793
HPRD ID		10527	03240
Ensembl ID		ENSG00000146872	ENSG00000150760
Uniprot IDs		B4DUC2 J3QLK5 Q86UE8	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs		5O0Y	3L4C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?