RALBP1 and REPS1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		RALBP1	REPS1
Description		ralA binding protein 1	RALBP1 associated Eps domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit
	Molecular Function	GTPase Activator Activity Protein Binding Transmembrane Transporter Activity Small GTPase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Endocytosis Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Doxorubicin Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Endocytosis Receptor-mediated Endocytosis Endosomal Transport Membrane Organization
Pathways		Rho GTPase cycle	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		LDL cholesterol ( 30275531)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Type 2 diabetes ( 32499647)
Interacting Genes		44 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CBY1 CCDC13 CCDC136 CCDC88B CCHCR1 CCNB1 CEP57 CREBZF FADD GAS8 GSE1 HOOK2 HSF1 IKBKG KANK2 LDOC1 MSANTD4 PCM1 PLCG2 PPP1R13B PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SAPCD2 SMARCE1 SYCE1 SYNJ2BP TBRG1 TCP10L TFPT TNIP1 TP53BP2 TRAF2 TSFM ZBTB38 ZNF707	17 interacting genes: ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2
Entrez ID		10928	85021
HPRD ID		09013	09687
Ensembl ID		ENSG00000017797	ENSG00000135597
Uniprot IDs		Q15311	B2R7D3 Q96D71
PDB IDs		2KWH 2KWI 2MBG
Enriched GO Terms of Interacting Partners?
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