REPS1 and ANKRD1

Data Source:
BioGRID (two hybrid)

		REPS1	ANKRD1
Description		RALBP1 associated Eps domain containing 1	ankyrin repeat domain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol I Band
	Molecular Function	Calcium Ion Binding Protein Binding SH3 Domain Binding	RNA Polymerase II Transcription Factor Binding P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosomal Transport Membrane Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Regulation Of Lipid Metabolic Process Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Protein Kinase C Signaling Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	PPARA activates gene expression
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Type 2 diabetes ( 32499647)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: ANKRD1 ATF4 CRK FLNC GRB2 HSF1 ITSN2 MZT1 PIN1 RAB11FIP2 RALA RALB RALBP1 REPS2 TRAPPC2 TRAPPC2L WWC2	23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446
Entrez ID		85021	27063
HPRD ID		09687	10647
Ensembl ID		ENSG00000135597	ENSG00000148677
Uniprot IDs		B2R7D3 Q96D71	A0A384NYH5 Q15327
PDB IDs
Enriched GO Terms of Interacting Partners?
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