BRD8 and TRRAP

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		BRD8	TRRAP
Description		bromodomain containing 8	transformation/transcription domain associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Swr1 Complex Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	SAGA Complex PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding	Transcription Coregulator Activity Protein Binding Kinase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus	DNA Repair Regulation Of Transcription, DNA-templated Phosphorylation Histone Acetylation Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Histone H2A Acetylation Beta-catenin-TCF Complex Assembly
Pathways		HATs acetylate histones	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		12 interacting genes: AGTR1 EP400 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1	18 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		10902	8295
HPRD ID		04166	04310
Ensembl ID		ENSG00000112983	ENSG00000196367
Uniprot IDs		B4DEG9 B4DMS9 B4DN43 Q9H0E9	Q9Y4A5
PDB IDs
Enriched GO Terms of Interacting Partners?
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