BRD8 and IL3

Data Source:
BioGRID (affinity chromatography technology)

		BRD8	IL3
Description		bromodomain containing 8	interleukin 3
Image		No pdb structure
GO Annotations	Cellular Component	Swr1 Complex Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus	MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		HATs acetylate histones	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling
Drugs			Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)	Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		12 interacting genes: AGTR1 EP400 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1	5 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD
Entrez ID		10902	3562
HPRD ID		04166	00987
Ensembl ID		ENSG00000112983	ENSG00000164399
Uniprot IDs		B4DEG9 B4DMS9 B4DN43 Q9H0E9	P08700
PDB IDs			1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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