YIF1A and ADAM17

Data Source:
BioGRID (affinity chromatography technology)

		YIF1A	ADAM17
Description		Yip1 interacting factor homolog A, membrane trafficking protein	ADAM metallopeptidase domain 17
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Integral Component Of Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft
	Molecular Function	Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity SH3 Domain Binding PDZ Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport IRE1-mediated Unfolded Protein Response	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Chemotaxis Protein Processing B Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Tumor Necrosis Factor-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Receptor Transactivation Response To Drug Amyloid Precursor Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Spleen Development Cell Motility Defense Response To Gram-positive Bacterium Positive Regulation Of Cellular Component Movement Cellular Response To High Density Lipoprotein Particle Stimulus Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		XBP1(S) activates chaperone genes	Nuclear signaling by ERBB4 Collagen degradation Signaling by EGFR Regulated proteolysis of p75NTR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Release of Hh-Np from the secreting cell TNF signaling CD163 mediating an anti-inflammatory response Growth hormone receptor signaling
Drugs			(3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Glucose homeostasis traits ( 25524916)	Birth weight ( 31043758) Offspring birth weight ( 31043758)
Interacting Genes		72 interacting genes: APOA5 AQP6 BNIP2 C4orf3 CD79A CDK2AP2 CERS2 CNRIP1 CST6 EBP ELOVL4 ERGIC3 FAM210B FARS2 FCER1G FFAR2 GAS7 GJA8 GPR37 GPR42 GPX8 HSD17B11 JOSD2 LNPK LSS MARCHF5 MGST3 MIEF2 MLLT1 MMGT1 MSMO1 MTERF3 MYG1 NDRG4 PLEKHF2 PPIF PTGES PTPN9 RBFA REEP2 REEP4 RIC3 RNF144A SCN3B SCN4B SDCBP SEC23IP SLC10A1 SLC34A1 SLC35C2 SNX10 SNX11 SNX2 SYTL2 SYTL5 TIMMDC1 TMEM139 TMEM14B TMEM17 TMEM225B TMEM248 TMEM31 TMX2 VKORC1 VMA21 WDFY2 YIPF4 YIPF5 ZDHHC16 ZDHHC17 ZFYVE21 ZFYVE27	14 interacting genes: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11
Entrez ID		10897	6868
HPRD ID		06755	04703
Ensembl ID		ENSG00000174851	ENSG00000151694
Uniprot IDs		A6NGW1 A8K509 O95070	B2RNB2 P78536
PDB IDs			1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?
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