PPARGC1A and THRB

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PPARGC1A	THRB
Description		PPARG coactivator 1 alpha	thyroid hormone receptor beta
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Cytosolic Ribosome Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Dendrite Subsarcolemmal Mitochondrion Interfibrillar Mitochondrion	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peroxisome Proliferator Activated Receptor Binding Alpha-tubulin Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Reactive Oxygen Species Autophagy Of Mitochondrion Temperature Homeostasis Cellular Glucose Homeostasis Negative Regulation Of Protein Phosphorylation Response To Dietary Excess Response To Ischemia Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Aging Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Skeletal Muscle Atrophy Response To Muscle Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Cerebellum Development Respiratory Electron Transport Chain Forebrain Development Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Cellular Response To Potassium Ion Response To Drug Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Flavone Metabolic Process Adipose Tissue Development Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Nitrite Cellular Response To Caffeine Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Response To Norepinephrine Negative Regulation Of Mitochondrial Fission Energy Homeostasis Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Metformin Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process Cellular Response To Ionomycin Cellular Response To Resveratrol Response To Methionine Adaptive Thermogenesis Positive Regulation Of Progesterone Biosynthetic Process Negative Regulation Of Signaling Receptor Activity Regulation Of NMDA Receptor Activity Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)
Interacting Genes		43 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RARB RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2	58 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3
Entrez ID		10891	7068
HPRD ID		05155	07521
Ensembl ID		ENSG00000109819	ENSG00000151090
Uniprot IDs		A0A024R9Q9 Q9UBK2	A0A024R2I8 P10828
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6W9K 6W9L	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW
Enriched GO Terms of Interacting Partners?
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