PPARGC1A and NCOA6

Data Source:
BioGRID (pull down)

		PPARGC1A	NCOA6
Description		PPARG coactivator 1 alpha	nuclear receptor coactivator 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Cytosolic Ribosome Neuronal Cell Body Intracellular Membrane-bounded Organelle Apical Dendrite Subsarcolemmal Mitochondrion Interfibrillar Mitochondrion	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Histone Methyltransferase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Peroxisome Proliferator Activated Receptor Binding Alpha-tubulin Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding	Chromatin Binding Transcription Coactivator Activity Protein Binding Enzyme Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Hormone Receptor Binding
	Biological Process	Response To Reactive Oxygen Species Autophagy Of Mitochondrion Temperature Homeostasis Cellular Glucose Homeostasis Negative Regulation Of Protein Phosphorylation Response To Dietary Excess Response To Ischemia Galactose Metabolic Process Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Aging Digestion Circadian Rhythm Androgen Metabolic Process RNA Splicing Response To Cold Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Skeletal Muscle Atrophy Response To Muscle Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Negative Regulation Of Smooth Muscle Cell Migration Fatty Acid Oxidation Cerebellum Development Respiratory Electron Transport Chain Forebrain Development Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Positive Regulation Of Histone Acetylation Cellular Response To Potassium Ion Response To Drug Response To Starvation Regulation Of Circadian Rhythm Response To Leucine Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Flavone Metabolic Process Adipose Tissue Development Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Nitrite Cellular Response To Caffeine Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Response To Norepinephrine Negative Regulation Of Mitochondrial Fission Energy Homeostasis Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuron Death Response To Metformin Positive Regulation Of Cellular Respiration Positive Regulation Of Mitochondrial DNA Metabolic Process Positive Regulation Of Muscle Tissue Development Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process Cellular Response To Ionomycin Cellular Response To Resveratrol Response To Methionine Adaptive Thermogenesis Positive Regulation Of Progesterone Biosynthetic Process Negative Regulation Of Signaling Receptor Activity Regulation Of NMDA Receptor Activity Positive Regulation Of ATP Biosynthetic Process	DNA-templated Transcription, Initiation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Response To Hormone Regulation Of Lipid Metabolic Process Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Bipolar disorder ( 31043756) Coronary artery disease ( 29212778) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling nervous ( 29500382) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		43 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RARB RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2	62 interacting genes: AR ASCC1 ATF2 CD40 CEBPA CREBBP E2F1 EP300 ESR1 ESR2 FHOD1 FOS GHR GRIP1 GTF2A1 H3C14 HNF4A HSF1 JUN LAMTOR5 MED1 MED23 NCOR2 NFKB1 NR1H2 NR1H3 NR1H4 NR1I2 NR3C1 NUMA1 PARP1 PPARG PPARGC1A PRKDC PRMT2 RANBP9 RARA RB1 RBM14 RBM39 RELA RORB RORC RXRA RXRG SMAD2 SMAD3 SRC SRF TBP TGS1 THRA THRB TOP1 TRA TRB TXNRD2 UBC VDR XRCC5 XRCC6 ZNF335
Entrez ID		10891	23054
HPRD ID		05155	05599
Ensembl ID		ENSG00000109819	ENSG00000198646
Uniprot IDs		A0A024R9Q9 Q9UBK2	F6M2K2 F6M2K3 Q14686
PDB IDs		1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6W9K 6W9L
Enriched GO Terms of Interacting Partners?
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