GPR83 and MRE11

Data Source:
BioGRID (proximity labelling technology)

		GPR83	MRE11
Description		G protein-coupled receptor 83	MRE11 homolog, double strand break repair nuclease
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Integral Component Of Membrane Non-motile Cilium	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break
	Molecular Function	G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity 5'-3' Exonuclease Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Response To Glucocorticoid	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Viral Process Intra-S DNA Damage Checkpoint Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Kinase Activity Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Signal Transduction By P53 Class Mediator
Pathways		G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Metabolite levels ( 23823483) Obstructive sleep apnea trait (apnea hypopnea index) ( 26977737) Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) ( 22566498)
Interacting Genes			20 interacting genes: ATM ATR CCNE1 CDK2 DCLRE1C DYNLL1 EP300 FANCD2 H2AX LIG1 MAPK8IP2 NBN NEK1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6
Entrez ID		10888	4361
HPRD ID		16125	02889
Ensembl ID		ENSG00000123901	ENSG00000020922
Uniprot IDs		F5GZ43 Q9NYM4	A0A024R395 F8W7U8 P49959 Q05D78
PDB IDs			3T1I
Enriched GO Terms of Interacting Partners?
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