CGA and LHCGR

Data Source:
HPRD (in vitro)

		CGA	LHCGR
Description		glycoprotein hormones, alpha polypeptide	luteinizing hormone/choriogonadotropin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Follicle-stimulating Hormone Complex	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Protein Binding Follicle-stimulating Hormone Activity	Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Generation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Peptide Hormone Processing Positive Regulation Of Cell Migration Positive Regulation Of Transcription By RNA Polymerase II	Ovarian Follicle Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Male Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Cognition Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus
Pathways		Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Thyroxine biosynthesis Hormone ligand-binding receptors G alpha (s) signalling events TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ADORA2B mediated anti-inflammatory cytokines production Reactions specific to the complex N-glycan synthesis pathway	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Atrial fibrillation ( 30061737 29892015) Thyroid stimulating hormone levels ( 32769997)	Body mass index ( 28892062) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776) Triglyceride levels ( 32154731)
Interacting Genes		9 interacting genes: CGB3 CGB5 FSHB FSHR LHB LHCGR PTN PTPN12 TSHB	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR
Entrez ID		1081	3973
HPRD ID		00342	01073
Ensembl ID		ENSG00000135346	ENSG00000138039
Uniprot IDs		A0A087WYZ4 P01215 Q6I9S8	P22888
PDB IDs		1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XUL 1XWD 4AY9 4MQW	1LUT 1XUL
Enriched GO Terms of Interacting Partners?
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