ADCY1 and SERTAD1

Data Source:
BioGRID (enzymatic study)

		ADCY1	SERTAD1
Description		adenylate cyclase 1	SERTA domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleus Cytoplasm
	Molecular Function	Adenylate Cyclase Activity Calmodulin Binding ATP Binding Calcium- And Calmodulin-responsive Adenylate Cyclase Activity Metal Ion Binding	Protein Binding Transcription Regulator Activity
	Biological Process	Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Axonogenesis Brain Development Long-term Memory Circadian Rhythm Response To Lithium Ion CAMP-mediated Signaling Positive Regulation Of CREB Transcription Factor Activity Activation Of Protein Kinase A Activity Response To Drug Regulation Of Circadian Rhythm Cellular Response To Calcium Ion Cellular Response To Glucagon Stimulus Neuroinflammatory Response Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Forskolin Regulation Of Synaptic Vesicle Exocytosis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Adenosine phosphate ATP Aurothioglucose
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Night sleep phenotypes ( 27126917) Subjective response to lithium treatment in bipolar disorder ( 26503763)	Monocyte percentage of white cells ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)
Interacting Genes		4 interacting genes: ADCY2 FZD7 GNAI2 SERTAD1	55 interacting genes: ADCY1 ASB8 ATG12 ATXN7L3 BANF2 C1orf109 CCND2 CDK4 CDKN2A CHAF1A CHURC1 CIB3 CINP CKS1B COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAAP20 FAH FNDC11 GLYCTK HIVEP1 HSPB1 KAT2B KLC4 KLHL42 MVP NEDD4 P4HA3 PATE1 PBX4 PICK1 PIH1D2 POT1 PRDM4 PSORS1C2 RBX1 RCHY1 ROPN1 SEC14L4 SETD7 SFI1 SMAD3 SPEN SSX7 STAT5B SUPT7L TGM2 TLR4 TRIM28 XIAP ZNF410
Entrez ID		107	29950
HPRD ID		00053	15326
Ensembl ID		ENSG00000164742	ENSG00000197019
Uniprot IDs		C9J1J0 Q08828	Q53GC0 Q9UHV2
PDB IDs
Enriched GO Terms of Interacting Partners?
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