SERTAD1 and DENND4A

Data Source:
BioGRID (two hybrid)

		SERTAD1	DENND4A
Description		SERTA domain containing 1	DENN domain containing 4A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Transcription Regulator Activity	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription	Regulation Of Transcription, DNA-templated Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Monocyte percentage of white cells ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 29403010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		55 interacting genes: ADCY1 ASB8 ATG12 ATXN7L3 BANF2 C1orf109 CCND2 CDK4 CDKN2A CHAF1A CHURC1 CIB3 CINP CKS1B COPB1 CREBBP DENND4A EGLN3 ELOC EP300 FAAP20 FAH FNDC11 GLYCTK HIVEP1 HSPB1 KAT2B KLC4 KLHL42 MVP NEDD4 P4HA3 PATE1 PBX4 PICK1 PIH1D2 POT1 PRDM4 PSORS1C2 RBX1 RCHY1 ROPN1 SEC14L4 SETD7 SFI1 SMAD3 SPEN SSX7 STAT5B SUPT7L TGM2 TLR4 TRIM28 XIAP ZNF410	7 interacting genes: C1QTNF9 CEBPE CLK1 PCBD1 SERTAD1 TLX3 YWHAG
Entrez ID		29950	10260
HPRD ID		15326	02662
Ensembl ID		ENSG00000197019	ENSG00000174485
Uniprot IDs		Q53GC0 Q9UHV2	Q05C90 Q7Z401
PDB IDs
Enriched GO Terms of Interacting Partners?
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