KLF1 and SMARCC1

Data Source:
HPRD (in vitro)

		KLF1	SMARCC1
Description		Kruppel like factor 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Maternal Process Involved In Female Pregnancy Cellular Response To Peptide	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases		Congenital dyserythropoietic anemias (CDAs)
GWAS		Clozapine-induced agranulocytosis ( 25187353) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498)
Interacting Genes		32 interacting genes: ARID1A C1QBP CCDC57 CREBBP CSNK2A1 CSNK2A2 DVL3 EFEMP2 EP300 FLI1 GYS1 HDAC1 HNRNPF HNRNPK MKRN3 PATZ1 PCBP1 PRKACA PRR3 RBM10 RBM4B RBPMS2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SNRPC TIAL1 TLE5 VPS37C	53 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PRMT5 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 TAF15 TRIM42 UFSP1 VGLL3 ZNF581
Entrez ID		10661	6599
HPRD ID		07197	03435
Ensembl ID		ENSG00000105610	ENSG00000173473
Uniprot IDs		Q13351	Q58EY4 Q92922
PDB IDs		2L2I 2MBH 2N23	2YUS 5GJK 6KZ7
Enriched GO Terms of Interacting Partners?
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