HEXIM1 and UBE2O

Data Source:
BioGRID (enzymatic study)

		HEXIM1	UBE2O
Description		HEXIM P-TEFb complex subunit 1	ubiquitin conjugating enzyme E2 O
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle 7SK SnRNP	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding P-TEFb Complex Binding	RNA Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator	Protein Monoubiquitination Negative Regulation Of Endopeptidase Activity Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Apoptotic Process Protein K63-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Insomnia ( 32332799) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 HEXIM2 RELA RN7SK TERF1 TERF2 UBE2O	17 interacting genes: APPL1 BAP1 CPNE1 CPNE2 CPNE4 HEXIM1 ITCH MAF MDM2 PRKN RNF10 RNF31 SFMBT2 SHBG TRIM27 UBC UBE2D3
Entrez ID		10614	63893
HPRD ID		09544	10928
Ensembl ID		ENSG00000186834	ENSG00000175931
Uniprot IDs		O94992	Q9C0C9
PDB IDs		2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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