TOP2B and SUMO1

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TOP2B	SUMO1
Description		DNA topoisomerase II beta	small ubiquitin like modifier 1
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule
	Molecular Function	DNA Binding Chromatin Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Ubiquitin-specific Protease Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change Axonogenesis Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of Transcription, DNA-templated Protein Stabilization Roof Of Mouth Development Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		SUMOylation of DNA replication proteins	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		Dexrazoxane Daunorubicin Etoposide Dactinomycin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		17 interacting genes: CD3E CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 RANBP2 RARA SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBE2I XPO1 XRCC5	151 interacting genes: AR ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 C18orf25 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SAE1 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN XPO1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451
Entrez ID		7155	7341
HPRD ID		00537	03554
Ensembl ID		ENSG00000077097	ENSG00000116030
Uniprot IDs		Q02880 Q59H80	A0A024R3Z2 P63165
PDB IDs		3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF	1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3
Enriched GO Terms of Interacting Partners?
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