SEMA3C and NRP2

Data Source:
HPRD (in vivo)

		SEMA3C	NRP2
Description		semaphorin 3C	neuropilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Extracellular Exosome	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Axon Guidance Post-embryonic Development Neural Tube Development Positive Regulation Of Cell Migration Response To Drug Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Cardiac Endothelial To Mesenchymal Transition Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Viral Process Facial Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor
Pathways			Neurophilin interactions with VEGF and VEGFR NrCAM interactions
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Blood protein levels ( 30072576 29875488) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 27841878) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) HDL cholesterol ( 27036123) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010) Intraocular pressure ( 29617998 31959993 30054594 29235454) Metabolite levels ( 23823483) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Rosacea symptom severity ( 29771307)	Blood protein levels ( 30072576 29875488) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)
Interacting Genes		2 interacting genes: NRP1 NRP2	11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		10512	8828
HPRD ID		04034	03643
Ensembl ID		ENSG00000075223	ENSG00000118257
Uniprot IDs		Q99985	O60462 Q7Z3T9
PDB IDs			2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8
Enriched GO Terms of Interacting Partners?
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