GPNMB and ITSN2

Data Source:
BioGRID (two hybrid)

		GPNMB	ITSN2
Description		glycoprotein nmb	intersectin 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Melanosome Membrane	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse
	Molecular Function	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Endocytosis Viral Process Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		PTK6 promotes HIF1A stabilization	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Glembatumumab vedotin
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Iron status biomarkers (transferrin saturation) ( 28334935) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		4 interacting genes: EGFR ITSN2 LINC01139 SMAD4	75 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		10457	50618
HPRD ID		05081	09193
Ensembl ID		ENSG00000136235	ENSG00000198399
Uniprot IDs		A0A024RA55 Q14956 Q96F58	A6H8W8 Q9NZM3
PDB IDs			1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
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