VAV3 and RHOG

Data Source:
HPRD (in vitro)

		VAV3	RHOG
Description		vav guanine nucleotide exchange factor 3	ras homolog family member G
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Angiogenesis Vesicle Fusion Cellular Response To DNA Damage Stimulus G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Neutrophil Degranulation Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	GPVI-mediated activation cascade PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Asthma and hay fever ( 24388013) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Differentiated thyroid cancer ( 28703219) Eosinophil percentage of white cells ( 32888494) Hashimoto thyroiditis versus Graves' disease ( 25429627) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 30367059 27182965 22493691) IgA nephropathy ( 25305756) Medication use (thyroid preparations) ( 31015401) Night sleep phenotypes ( 27126917) Papillary thyroid cancer ( 28703219) Plasma thyroid-stimulating hormone levels ( 24722205) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Thyroid stimulating hormone levels ( 32769997)	Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		25 interacting genes: AR CBLB EGFR ERBB2 ERBB3 ERBB4 ESR1 GAB1 GRB2 IGF1R INSR KIT LCP2 MET PIK3R1 PLCG1 RAC1 RHOA RHOG RINT1 ROS1 SH3BP2 SHC1 ZRANB1 ZYX	21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		10451	391
HPRD ID		05706	01537
Ensembl ID		ENSG00000134215	ENSG00000177105
Uniprot IDs		Q9UKW4	P84095 Q6ICQ8
PDB IDs		2D86	6UKA
Enriched GO Terms of Interacting Partners?
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