IFITM3 and SLC10A2

Data Source:
BioGRID (two hybrid)

		IFITM3	SLC10A2
Description		interferon induced transmembrane protein 3	solute carrier family 10 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding Bile Acid:sodium Symporter Activity
	Biological Process	Immune Response Response To Virus Negative Regulation Of Viral Transcription Response To Interferon-gamma Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Type I Interferon Signaling Pathway	Sodium Ion Transport Bile Acid And Bile Salt Transport Transmembrane Transport
Pathways		Interferon alpha/beta signaling	Recycling of bile acids and salts
Drugs			Volixibat
Diseases			Primary bile acid malabsorption
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) epithelial cell adhesion molecule levels ( 25147954) Esophageal cancer (alcohol interaction) ( 22960999) Gallstone disease ( 30504769) Late-onset Alzheimer's disease ( 27770636) Metabolite levels ( 23823483) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Response to quetiapine in schizophrenia ( 29503163) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		27 interacting genes: ABHD16A AQP6 CD53 ELOVL2 ERGIC3 FAM210B FFAR2 FKBP7 GLP1R GPR37 GPRC5D KIR2DL3 LYPD5 MS4A3 NEDD4 OPRM1 PLP1 PTAFR REEP4 RETREG3 SGPL1 SLC10A1 SLC10A2 SLC16A7 TMEM14B TMEM86B VKORC1	10 interacting genes: C3orf52 CCL4L2 CTXN3 EFNA5 IFITM3 NRM PSENEN TEX264 TMEM222 UPK1B
Entrez ID		10410	6555
HPRD ID		05719	03189
Ensembl ID		ENSG00000142089	ENSG00000125255
Uniprot IDs		Q01628	Q12908
PDB IDs
Enriched GO Terms of Interacting Partners?
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