CDSN and KLK7

Data Source:
BioGRID (enzymatic study)

		CDSN	KLK7
Description		corneodesmosin	kallikrein related peptidase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Plasma Membrane Cell-cell Junction Desmosome	Extracellular Region Extracellular Space Secretory Granule Epidermal Lamellar Body
	Molecular Function	Protein Homodimerization Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Corneocyte Desquamation Cell Adhesion Epidermis Development Keratinocyte Differentiation Skin Morphogenesis Cornification Cell-cell Adhesion Negative Regulation Of Cornification	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly
Pathways		Formation of the cornified envelope	Degradation of the extracellular matrix
Drugs			L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Diseases		Hypotrichosis simplex of scalp
GWAS		Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 28240269) Hematology traits ( 23263863) Hemoglobin levels ( 32327693) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Multiple myeloma ( 23955597) Schizophrenia ( 28991256) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) White blood cell count ( 20139978 21738480)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		37 interacting genes: ASPH ATXN1L BAG6 BANP CCHCR1 CEP55 CSTF2 CSTF2T CTNNA3 DESI1 EIF3F ENKD1 EXOC8 FAM9B HGS HPCAL4 ITPRIPL1 KCNIP3 KLK7 LCN2 NCS1 NELFCD PARVG PLVAP PRKAB2 SGTA SGTB SMARCD1 TGM7 TRIM69 TSGA10 UBQLN1 UBQLN2 UBQLN4 UCHL5 VSNL1 ZDHHC17	10 interacting genes: APP BAG4 CCND1 CDSN CHEK2 PTPN1 PTPRJ STK11 TGFB1 WT1
Entrez ID		1041	5650
HPRD ID		03998	05115
Ensembl ID		ENSG00000204539	ENSG00000169035
Uniprot IDs		G8JLG2 Q15517	A0A024R4H6 B4DHX9 P49862
PDB IDs			2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK 6SHH 6SHI 6SJU 6Y4S
Enriched GO Terms of Interacting Partners?
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