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TFG and PTPN6
Data Source:
HPRD
(in vivo, in vitro)
TFG
PTPN6
Description
trafficking from ER to golgi regulator
protein tyrosine phosphatase non-receptor type 6
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Endoplasmic Reticulum Exit Site
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Protein Binding
Identical Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
COPII Vesicle Coating
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Cytokine Stimulus
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
COPII-mediated vesicle transport
GPVI-mediated activation cascade
Regulation of KIT signaling
PECAM1 interactions
Costimulation by the CD28 family
PD-1 signaling
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Tiludronic acid
Diseases
Non-small cell lung cancer
Thyroid cancer
GWAS
Refractive error (
32231278
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Interacting Genes
73 interacting genes:
ANXA11
ARHGEF16
ARL15
BOLL
BPIFA1
C19orf54
CEP126
CEP55
CRMP1
CRX
CSTF2
DAZAP2
DVL3
ERG28
EWSR1
EYA2
FAM168A
FOXH1
GBP2
GPRASP1
GRB2
HGS
HNRNPF
INCA1
INTS11
KHDC1
KRTAP26-1
LASP1
LENG8
MAGED1
MAPK1IP1L
MED21
MED25
METTL27
MSS51
MYOT
NADSYN1
NID2
OXER1
PEF1
PFDN5
PIN1
PLA2G10
PLEKHG4
PLSCR1
POU2AF1
PPP1R32
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPN6
RBPMS
RIPPLY2
RNF4
SEC24A
SF3A2
SF3B4
SMUG1
SPG21
STAT5B
STH
TBX19
TEX37
TRIM25
TSSK2
UBAP2
UBE2I
VPS37C
WWOX
ZMYM5
ZNF34
114 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
10342
5777
HPRD ID
03932
01475
Ensembl ID
ENSG00000114354
ENSG00000111679
Uniprot IDs
Q05BK6
Q92734
P29350
Q53XS4
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
Enriched GO Terms of Interacting Partners
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