PTPN6 and ROR1

Data Source:
BioGRID (two hybrid)

		PTPN6	ROR1
Description		protein tyrosine phosphatase non-receptor type 6	receptor tyrosine kinase like orphan receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Axon Terminus
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Platelet Formation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Cytokine Stimulus Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		GPVI-mediated activation cascade Regulation of KIT signaling PECAM1 interactions Costimulation by the CD28 family PD-1 signaling Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs		Tiludronic acid
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)	Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		114 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70	13 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX
Entrez ID		5777	4919
HPRD ID		01475	03821
Ensembl ID		ENSG00000111679	ENSG00000185483
Uniprot IDs		P29350 Q53XS4	Q01973
PDB IDs		1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ	5Z55 6BA5 6BAN 6TU9
Enriched GO Terms of Interacting Partners?
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