CDKN2D and NR4A3

Data Source:
BioGRID (two hybrid)

		CDKN2D	NR4A3
Description		cyclin dependent kinase inhibitor 2D	nuclear receptor subfamily 4 group A member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cyclin D2-CDK4 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair Cell Cycle Arrest Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Response To UV Negative Regulation Of Cell Growth Response To Retinoic Acid Response To Vitamin D Negative Regulation Of Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Autophagic Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Gastrulation Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Intracellular Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs			Dasatinib
Diseases			Extraskeletal myxoid chondrosarcoma
GWAS		Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)	Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424)
Interacting Genes		63 interacting genes: APP BRCA1 BTG1 C1orf94 C5orf49 CCND3 CDK4 CDK6 CGGBP1 CTBP1 DDIT4L DMRTB1 DYNLT2B EIF4G1 FAM228A FAM86C1P FHL3 GATAD2B GLYR1 GORASP2 GSC2 HSD17B14 IKZF3 INCA1 KRT75 LNX1 LONRF1 LSM3 MEI4 MEOX2 MSS51 MTF2 NDUFB7 NIF3L1 NME4 NMI NR4A1 NR4A2 NR4A3 PICK1 PRDX5 PRIMPOL PSMA1 QKI REL RUFY4 SAXO1 SDCBP SH3GLB1 SH3GLB2 TBC1D17 TEX11 THAP1 TSG101 TSGA10IP UQCC2 VGLL1 YPEL3 ZBTB32 ZNF396 ZNF620 ZNF688 ZNF774	43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330
Entrez ID		1032	8013
HPRD ID		02957	02766
Ensembl ID		ENSG00000129355	ENSG00000119508
Uniprot IDs		A0A024R796 P55273	A0A024R168 Q92570
PDB IDs		1BD8 1BI8
Enriched GO Terms of Interacting Partners?
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