TCIRG1 and TLX3

Data Source:
BioGRID (two hybrid)

		TCIRG1	TLX3
Description		T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	T cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Ficolin-1-rich Granule Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Ossification Osteoclast Proliferation Cellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Transferrin Transport Ion Transmembrane Transport Memory T Cell Activation T-helper 1 Cell Activation T Cell Homeostasis Neutrophil Degranulation Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation Regulation Of Insulin Secretion Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)	Body size at age 10 ( 32376654)
Interacting Genes		6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3	106 interacting genes: ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C11orf1 C11orf45 C19orf54 C2orf42 CEACAM6 CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM166B FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 TEX37 THTPA TLE1 TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		10312	30012
HPRD ID		05207	06868
Ensembl ID		ENSG00000110719	ENSG00000164438
Uniprot IDs		A0A024R5E5 Q13488	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?
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