STAM2 and FAM189A2

Data Source:
BioGRID (two hybrid)

		STAM2	FAM189A2
Description		signal transducing adaptor molecule 2	family with sequence similarity 189 member A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle	Cellular_component Integral Component Of Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization	Biological_process
Pathways		EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)	Coronary artery disease in type 1 diabetes ( 29695241)
Interacting Genes		39 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN2 UBQLN4 USP8 VPS37C XRN1 ZC3H10	10 interacting genes: BAG3 CALCOCO2 OPTN SFN STAM2 TAX1BP1 UBQLN1 UBXN1 WWP1 WWP2
Entrez ID		10254	9413
HPRD ID		05876	16255
Ensembl ID		ENSG00000115145	ENSG00000135063
Uniprot IDs		O75886	A0A0A0MR12 A0A6F8PH59 Q15884 Q8WU02
PDB IDs		1X2Q 1X5B 2L0T 5CRV 5IXF
Enriched GO Terms of Interacting Partners?
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