GPHN and GLRB

Data Source:
HPRD (in vivo, in vitro)

		GPHN	GLRB
Description		gephyrin	glycine receptor beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Dendrite Postsynaptic Membrane Synaptic Membrane Anchored Component Of Synaptic Membrane Postsynaptic Specialization Postsynaptic Specialization Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Glycine-gated Chloride Channel Complex Dendrite Neuron Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding ATP Binding Nitrate Reductase Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Transmembrane Signaling Receptor Activity Chloride Channel Activity Protein Binding Glycine Binding Extracellularly Glycine-gated Ion Channel Activity Extracellularly Glycine-gated Chloride Channel Activity Neurotransmitter Receptor Activity Protein-containing Complex Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Glycine Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Postsynaptic Neurotransmitter Receptor Diffusion Trapping	Startle Response Ion Transport Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Acrosome Reaction Nervous System Development Visual Perception Adult Walking Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Response To Amino Acid Nervous System Process Synaptic Transmission, Glycinergic Righting Reflex Excitatory Postsynaptic Potential Gamma-aminobutyric Acid Receptor Clustering Chloride Transmembrane Transport
Pathways		Molybdenum cofactor biosynthesis	Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs		Formic acid Imidazole Propanoic acid	Glycine Lindane Memantine Seletracetam Cannabidiol Medical Cannabis Nabiximols
Diseases		Hyperekplexia	Hyperekplexia
GWAS		Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)	Cognitive decline (age-related) ( 28078323) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A	2 interacting genes: APP GPHN
Entrez ID		10243	2743
HPRD ID		04893	11751
Ensembl ID		ENSG00000171723	ENSG00000109738
Uniprot IDs		Q9NQX3	P48167
PDB IDs		1JLJ
Enriched GO Terms of Interacting Partners?
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