STX6 and EEA1

Data Source:
HPRD (in vitro)

		STX6	EEA1
Description		syntaxin 6	early endosome antigen 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Integral Component Of Membrane Clathrin-coated Vesicle Integral Component Of Synaptic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Perinuclear Region Of Cytoplasm	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Vesicle Fusion Endosome Organization Synaptic Vesicle To Endosome Fusion Endocytic Recycling Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Vesicle Docking Golgi Ribbon Formation Regulation Of Cellular Protein Localization	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport
Pathways		Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Toll Like Receptor 9 (TLR9) Cascade
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Creutzfeldt-Jakob disease (sporadic) ( 32949544) Menopause (age at onset) ( 26414677) Progressive supranuclear palsy ( 30089514 21685912) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		35 interacting genes: AQP6 ARMC8 DNAJC5 EBP EEA1 FAM210B GOLM2 GOPC LIME1 LMNA MARCHF2 MEOX2 MMGT1 MTERF2 MTIF3 NAPB PSMA3 PTPN9 SCN3B SNAP23 SNAP29 STOM STX16 STX1A STX2 STX4 STX7 TIMMDC1 TMEM14B TMEM205 TMEM86B TMEM9 VAMP4 VPS11 VPS18	13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		10228	8411
HPRD ID		07231	05460
Ensembl ID		ENSG00000135823	ENSG00000102189
Uniprot IDs		O43752	Q15075
PDB IDs		2NPS 4J2C	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?
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