EEA1 and RAB31

Data Source:
BioGRID (pull down)

		EEA1	RAB31
Description		early endosome antigen 1	RAB31, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome	Phagocytic Cup Early Endosome Cytosol Plasma Membrane Endomembrane System Secretory Granule Membrane Early Endosome Membrane Trans-Golgi Network Membrane Early Phagosome Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport	Intracellular Protein Transport Receptor Internalization Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Neutrophil Degranulation Regulated Exocytosis Positive Regulation Of Phagocytosis, Engulfment Phagosome Maturation
Pathways		Toll Like Receptor 9 (TLR9) Cascade	Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Age at first sexual intercourse ( 27089180) Basophil count ( 32888494) Blood pressure (age interaction) ( 24954895) Bone fracture in osteoporosis ( 28580392) Dupuytren's disease ( 28886342) Lung adenocarcinoma ( 28604730)
Interacting Genes		13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16	6 interacting genes: ALS2CL EEA1 EGFR MAPK6 MPP3 OCRL
Entrez ID		8411	11031
HPRD ID		05460	05751
Ensembl ID		ENSG00000102189	ENSG00000168461
Uniprot IDs		Q15075	Q13636
PDB IDs		1HYI 1HYJ 1JOC 3MJH	2FG5
Enriched GO Terms of Interacting Partners?
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