ARPC4 and ARPC5L

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		ARPC4	ARPC5L
Description		actin related protein 2/3 complex subunit 4	actin related protein 2/3 complex subunit 5 like
Image
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome	Cytoplasm Arp2/3 Protein Complex Focal Adhesion Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Molecular_function Protein Binding Actin Filament Binding
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization	Biological_process Cell Migration Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	2 interacting genes: ARPC4 GADD45G
Entrez ID		10093	81873
HPRD ID		10368	12490
Ensembl ID		ENSG00000241553	ENSG00000136950
Uniprot IDs		P59998	A0A024R897 B3KPC7 Q9BPX5
PDB IDs		6UHC 6YW6 6YW7	6YW6
Enriched GO Terms of Interacting Partners?
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