ARPC4 and METTL21A

Data Source:
BioGRID (two hybrid)

		ARPC4	METTL21A
Description		actin related protein 2/3 complex subunit 4	methyltransferase like 21A
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GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Protein Binding Protein Methyltransferase Activity Protein-lysine N-methyltransferase Activity Hsp70 Protein Binding Heat Shock Protein Binding ATPase Binding
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization	Protein Methylation Peptidyl-lysine Methylation Regulation Of ATPase Activity
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Protein methylation
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			HDL cholesterol levels ( 32203549) Opioid sensitivity ( 23183491) Systolic blood pressure ( 28135244 28739976 30578418)
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	15 interacting genes: ARPC4 ATRIP HSPA1A HSPA5 HSPA8 LNX1 LZTS1 MEI4 MEOX2 MSRB3 PFDN5 ZBED8 ZNF620 ZNF655 ZRANB1
Entrez ID		10093	151194
HPRD ID		10368	14090
Ensembl ID		ENSG00000241553	ENSG00000144401
Uniprot IDs		P59998	C9JES0 H7BXH9 Q8WXB1
PDB IDs		6UHC 6YW6 6YW7	4LEC
Enriched GO Terms of Interacting Partners?
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