CHAF1A and DDX41

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CHAF1A	DDX41
Description		chromatin assembly factor 1 subunit A	DEAD-box helicase 41
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Protein-containing Complex CAF-1 Complex	Nucleus Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	DNA Replication DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Cell Cycle Chromatin Assembly	MRNA Splicing, Via Spliceosome Apoptotic Process Cell Population Proliferation Cell Differentiation Positive Regulation Of Type I Interferon Production
Pathways			STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B CREBBP DBF4 DDX41 H3-4 H3C6 HMGB2 LZTR1 MBD1 MEI4 MSH6 NOTO PABPC1 PAX6 PCBD2 PCNA POU6F2 RBFOX2 REL SERTAD1 SET SPOP STAT5B SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIB3 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408 ZNF620	7 interacting genes: AIDA CEP70 CHAF1A KLC2 NKAPL SIAH1 TUBG1
Entrez ID		10036	51428
HPRD ID		03148	10490
Ensembl ID		ENSG00000167670	ENSG00000183258
Uniprot IDs		Q13111	B3KRK2 Q9UJV9
PDB IDs			2P6N 5GVR 5GVS 5H1Y
Enriched GO Terms of Interacting Partners?
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