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TANK and ZC3H12A
Data Source:
BioGRID
(pull down)
HPRD
(two hybrid)
TANK
ZC3H12A
Description
TRAF family member associated NFKB activator
zinc finger CCCH-type containing 12A
Image
GO Annotations
Cellular Component
Cytosol
Protein-containing Complex
P-body
Nucleus
Nucleoplasm
Cytoplasm
Rough Endoplasmic Reticulum
Cytoskeleton
Rough Endoplasmic Reticulum Membrane
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Extrinsic Component Of Endoplasmic Reticulum Membrane
Molecular Function
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Deubiquitinase Activator Activity
Metal Ion Binding
DNA Binding
Chromatin Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Endoribonuclease Activity
Exoribonuclease Activity
Ribonuclease Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
MiRNA Binding
RNA Stem-loop Binding
MRNA 3'-UTR AU-rich Region Binding
Ribosome Binding
Metal Ion Binding
Biological Process
Proteolysis
Cellular Response To DNA Damage Stimulus
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Viral Process
Protein Phosphopantetheinylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ionizing Radiation
Positive Regulation Of Protein Deubiquitination
Positive Regulation Of Ubiquitin-specific Protease Activity
Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Defense Response To Virus By Host
Immune Response-activating Signal Transduction
Apoptotic Process
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Nervous System Development
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Muscle Cell Apoptotic Process
Positive Regulation Of Lipid Storage
Positive Regulation Of Cell Death
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
Cell Differentiation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Response To Oxidative Stress
Cellular Response To Glucose Starvation
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Macrophage Activation
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation By Host Of Viral Genome Replication
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Protein Complex Oligomerization
Defense Response To Virus
Negative Regulation Of Cardiac Muscle Contraction
Positive Regulation Of MRNA Catabolic Process
3'-UTR-mediated MRNA Destabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
RNA Phosphodiester Bond Hydrolysis
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Response To Virus
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of P38MAPK Cascade
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein Deubiquitination
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Cellular Response To Sodium Arsenite
Cellular Response To Ionomycin
Cellular Response To Chemokine
Negative Regulation Of T-helper 17 Cell Differentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of MiRNA Catabolic Process
Pathways
TICAM1-dependent activation of IRF3/IRF7
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS
Alcohol consumption (
27911795
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
30696823
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Dietary macronutrient intake (
23372041
)
Educational attainment (
25201988
)
Educational attainment (years of education) (
23722424
)
Extremely high intelligence (
29520040
)
General cognitive ability (
29844566
)
Household income (MTAG) (
31844048
)
Obesity-related traits (
23251661
)
Presence of antiphospholipid antibodies (
23509613
)
Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) (
24554482
)
Smoking status (ever vs never smokers) (
30643258
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Subcutaneous adipose tissue (
22589738
)
Tourette syndrome (
30818990
)
Treatment response for severe sepsis (
22310353
)
Weight (
31647587
)
Eyebrow thickness (
26926045
)
Mean corpuscular hemoglobin (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
31 interacting genes:
AIMP2
APBA3
APP
ATP6V1H
BIK
CD40
CHUK
COPB1
FBLN1
HLA-C
IKBKB
IKBKE
IKBKG
INPP5K
KPNA2
LAMC1
MAP4K5
MARCHF5
PLK1
RACGAP1
SDC4
SMAD3
SRSF11
TBK1
TP53BP2
TRAF1
TRAF2
TRAF3
TRAF6
USP7
ZC3H12A
19 interacting genes:
AHSP
AIMP2
BTRC
CYFIP2
DNAJB13
EP300
HIF1A
IKBKG
IL6
IRAK2
KPNA2
P4HA3
SHBG
SMAD3
TANK
TRIM55
TRIM63
UBC
ZC3H12D
Entrez ID
10010
80149
HPRD ID
04870
08021
Ensembl ID
ENSG00000136560
ENSG00000163874
Uniprot IDs
B2R7S3
Q6NW12
Q92844
Q5D1E8
PDB IDs
1KZZ
1L0A
5H10
3V32
3V33
3V34
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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