TANK and HLA-C

Data Source:
BioGRID (two hybrid)

		TANK	HLA-C
Description		TRAF family member associated NFKB activator	major histocompatibility complex, class I, C
Image
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding	Protein Binding Peptide Antigen Binding TAP Binding
	Biological Process	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Viral Process Protein Phosphopantetheinylation TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Neutrophil Degranulation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)	AIDS progression ( 19115949) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood cell traits (multivariate analysis) ( 31080455) Blood protein levels ( 29875488 28240269) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cervical cancer ( 28806749) Chickenpox ( 28928442) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 26582766) Chronic hepatitis B infection ( 25802187) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233 26891255) Cutaneous psoriasis ( 26626624) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling nervous ( 29500382) Feeling worry ( 29500382) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 23563607 31562340) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatitis B ( 24162738) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 26039976) Hypothyroidism ( 22493691) IgE levels ( 24324648) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 26582766) Leprosy ( 32421744) Leukoderma in response to rhododendrol ( 32558222) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Monocyte count ( 29403010 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Myositis ( 26291516) Nasopharyngeal carcinoma ( 20512145) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010 32888494 27863252) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Perceived unattractiveness to mosquitoes ( 28199695) Plantar warts ( 28928442) Pneumonia ( 28928442) Protein quantitative trait loci ( 18464913) Psoriasis ( 30921485 20953188 20953190 23143594 18369459 18364390 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Red blood cell count ( 32888494) Response to hepatitis B vaccine ( 29534301) Reticulocyte count ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Self-reported allergy ( 23817569) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severity of facial solar lentigines ( 27327535) Shingles ( 28928442) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Tonsillectomy ( 27182965 28928442) Tuberculosis ( 28928442) Ulcerative colitis ( 28067908) Vitiligo ( 20526339) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 29403010 32888494 27863252 21738480 28158719) White blood cell count (basophil) ( 29403010) White blood cell count (lymphocyte) ( 28158719)
Interacting Genes		31 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 USP7 ZC3H12A	24 interacting genes: B2M BATF2 CALR CD8A CDC25A GPR182 GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP YBX1
Entrez ID		10010	3107
HPRD ID		04870	00829
Ensembl ID		ENSG00000136560	ENSG00000204525
Uniprot IDs		B2R7S3 Q6NW12 Q92844	O19617 P10321 Q6R739 Q95HC2
PDB IDs		1KZZ 1L0A 5H10	1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO
Enriched GO Terms of Interacting Partners?
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