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MIP

Description major intrinsic protein of lens fiber
Image No pdb structure
GO Annotations Cellular Component
  • Endoplasmic Reticulum
  • Plasma Membrane
  • Integral Component Of Plasma Membrane
  • Gap Junction
  • Integral Component Of Membrane
  • Apical Plasma Membrane
Molecular Function
  • Structural Constituent Of Eye Lens
  • Protein Binding
  • Calmodulin Binding
  • Water Channel Activity
Biological Process
  • Lens Development In Camera-type Eye
  • Water Transport
  • Visual Perception
  • Positive Regulation Of Cell Adhesion
  • Response To Stimulus
  • Protein Homotetramerization
  • Transmembrane Transport
  • Gap Junction-mediated Intercellular Transport
Pathways
  • Passive transport by Aquaporins
Drugs
  • B-nonylglucoside
Diseases
GWAS
  • Axial length ( 24144296)
Interacting Genes 47 interacting genes: AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID 4284
HPRD ID 01098
Ensembl ID ENSG00000135517
Uniprot IDs P30301
PDB IDs
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025