MRC2 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		MRC2	PALB2
Description		mannose receptor C type 2	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Focal Adhesion Membrane Integral Component Of Membrane	Nucleoplasm Protein-containing Complex
	Molecular Function	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity	DNA Binding Protein Binding
	Biological Process	Osteoblast Differentiation Endocytosis Collagen Catabolic Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)	Bipolar disorder ( 17554300)
Interacting Genes		14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		9902	79728
HPRD ID		10094	07966
Ensembl ID		ENSG00000011028	ENSG00000083093
Uniprot IDs		Q9UBG0	H3BN63 Q86YC2
PDB IDs		5AO5 5AO6 5E4K 5E4L 5EW6	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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