PALB2 and IL13RA2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PALB2	IL13RA2
Description		partner and localizer of BRCA2	interleukin 13 receptor subunit alpha 2
Image
GO Annotations	Cellular Component	Nucleoplasm Protein-containing Complex	Extracellular Region Extracellular Space External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	DNA Binding Protein Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Negative Regulation Of Immunoglobulin Production Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of Mast Cell Degranulation
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001
Diseases
GWAS		Bipolar disorder ( 17554300)
Interacting Genes		32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	17 interacting genes: AKT1 BAG4 BRMS1 CASP8 EGFR ERBB2 ESR2 IGF1R IL13 IL4 IL4R NOTCH2 PALB2 PAX2 PIK3CA PLPP6 RB1CC1
Entrez ID		79728	3598
HPRD ID		07966	02132
Ensembl ID		ENSG00000083093	ENSG00000123496
Uniprot IDs		H3BN63 Q86YC2	Q14627
PDB IDs		2W18 3EU7	3LB6
Enriched GO Terms of Interacting Partners?
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