MRC2 and XRCC3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		MRC2	XRCC3
Description		mannose receptor C type 2	X-ray repair cross complementing 3
Image			No pdb structure
GO Annotations	Cellular Component	Focal Adhesion Membrane Integral Component Of Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Osteoblast Differentiation Endocytosis Collagen Catabolic Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways		Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		9902	7517
HPRD ID		10094	07201
Ensembl ID		ENSG00000011028	ENSG00000126215
Uniprot IDs		Q9UBG0	O43542 Q53XC8
PDB IDs		5AO5 5AO6 5E4K 5E4L 5EW6
Enriched GO Terms of Interacting Partners?
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