DCAF1 and RAG1

Number of citations of the paper that reports this interaction (PubMedID 22157821)
16

Data Source:
BioGRID (biochemical, pull down, affinity chromatography technology)

		DCAF1	RAG1
Description		DDB1 and CUL4 associated factor 1	recombination activating 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex
	Molecular Function	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Asthma ( 32296059)	Rheumatoid arthritis ( 24390342)
Interacting Genes		22 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IMPDH2 KATNA1 NF2 PRKDC PWP1 PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2 UBE2D3	22 interacting genes: APOF APP CAPRIN1 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 PAX6 RAG2 SNX6 TBCA UBC UBE2C UBE2D1 UBE2D2 UBE2H
Entrez ID		9730	5896
HPRD ID		11674	01556
Ensembl ID		ENSG00000145041	ENSG00000166349
Uniprot IDs		Q9Y4B6	P15918
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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