RAG1 and DCAF1

Number of citations of the paper that reports this interaction (PubMedID 22157821)
16

Data Source:
BioGRID (biochemical, pull down, affinity chromatography technology)

		RAG1	DCAF1
Description		recombination activating 1	DDB1 and CUL4 associated factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Recombinase Complex Endodeoxyribonuclease Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Endonuclease Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Double-stranded DNA Endodeoxyribonuclease Activity	Protein Binding ATP Binding Estrogen Receptor Binding Protein Serine Kinase Activity Histone Kinase Activity (H2A-T120 Specific)
	Biological Process	Adaptive Immune Response Pre-B Cell Allelic Exclusion DNA Recombination Immune Response Visual Learning Histone Monoubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of T Cell Differentiation Thymus Development Protein Autoubiquitination Negative Regulation Of Thymocyte Apoptotic Process Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Behavioral Fear Response	Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation
Pathways		Interleukin-7 signaling MAPK6/MAPK4 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 24390342)	Asthma ( 32296059)
Interacting Genes		22 interacting genes: APOF APP CAPRIN1 DCAF1 H2AC20 H2BC21 H3-4 H3C1 H4-16 HMGB1 HMGB2 KPNA1 KPNA2 PAX6 RAG2 SNX6 TBCA UBC UBE2C UBE2D1 UBE2D2 UBE2H	22 interacting genes: ATM ATR CCP110 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IMPDH2 KATNA1 NF2 PRKDC PWP1 PYGO2 RAG1 RBX1 SAMHD1 TET2 TP53 UBE2D2 UBE2D3
Entrez ID		5896	9730
HPRD ID		01556	11674
Ensembl ID		ENSG00000166349	ENSG00000145041
Uniprot IDs		P15918	Q9Y4B6
PDB IDs			3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45
Enriched GO Terms of Interacting Partners?
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