ECE2 and CD86

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ECE2	CD86
Description		endothelin converting enzyme 2	CD86 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Methyltransferase Activity Metal Ion Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Protein Processing Peptide Hormone Processing Methylation	Adaptive Immune Response Positive Regulation Of Immunoglobulin Production Immune Response Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cell Population Proliferation CD40 Signaling Pathway T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of NIK/NF-kappaB Signaling Activation Of Protein Kinase C Activity
Pathways		Peptide ligand-binding receptors	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Body mass index ( 29273807) Daytime nap ( 33568662) Major depressive disorder ( 22472876) Menarche (age at onset) ( 21102462)	Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		6 interacting genes: CASP10 CD53 CD86 MTNR1A SYNE4 UBC	15 interacting genes: CD28 CD80 CSTA CTLA4 ECE2 FXR1 INHBA KPNA1 MARCHF8 MCM2 P4HA2 PARP1 TEX55 TRA2A TRH
Entrez ID		9718	942
HPRD ID		09931	03011
Ensembl ID		ENSG00000145194	ENSG00000114013
Uniprot IDs		P0DPD6 P0DPD8	A0A0X9R4E0 A8K632 P42081
PDB IDs			1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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