MACROH2A1 and SPOP

Number of citations of the paper that reports this interaction (PubMedID 28805822)
78

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MACROH2A1	SPOP
Description		macroH2A.1 histone	speckle type BTB/POZ protein
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Dosage Compensation Regulation Of Lipid Metabolic Process Negative Regulation Of Histone Phosphorylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Gene Expression, Epigenetic Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K27 Methylation Regulation Of Ribosomal DNA Heterochromatin Assembly Establishment Of Protein Localization To Chromatin Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Hedgehog 'on' state
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Interacting Genes		21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622	68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		9555	8405
HPRD ID		13624	16004
Ensembl ID		ENSG00000113648	ENSG00000121067
Uniprot IDs		O75367	O43791
PDB IDs		1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D
Enriched GO Terms of Interacting Partners?
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