SPOP and BRD3

Number of citations of the paper that reports this interaction (PubMedID 31026449)
3

Data Source:
BioGRID (x-ray crystallography, pull down)

		SPOP	BRD3
Description		speckle type BTB/POZ protein	bromodomain containing 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II
Pathways		Hedgehog 'on' state
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Alanine aminotransferase levels ( 34315874) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Brain-derived neurotrophic factor levels ( 33345186) Central corneal thickness ( 31798171 29760442) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998 30591961) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 22139419 32888494) Platelet distribution width ( 27863252) Red cell distribution width ( 32888494 27863252 28957414) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	8 interacting genes: APP BRD7 KPNA3 MAP1LC3B MYC SPOP SPP1 TSC1
Entrez ID		8405	8019
HPRD ID		16004	03327
Ensembl ID		ENSG00000121067	ENSG00000169925
Uniprot IDs		O43791	A0A024R8H6 B4DS09 Q15059
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D	2E7N 2NXB 2OO1 2YW5 3S91 3S92 5A7C 5HFR 5HJC 6BGG 6BGH 6I41 6I5P 6I68 6I7A 6QJU 6U4A 6ULP 7JMY
Enriched GO Terms of Interacting Partners?
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